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Gram-Negative Bloodstream Infection

Friday 16 November 2018
De Vere West One Conference Centre, London

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This conference focuses on the effective management and reduction of Gram-negative bloodstream infection in line the National Programme ambition to halve healthcare associated Gram-negative bloodstream infections by March 2021.

“The case for addressing infections within the NHS is clear…if we can achieve these reductions, the benefit to patients is immense.” Ruth May Executive Director of Nursing, NHS Improvement, Deputy CNO & National Director for Infection Prevention and Control

“Bacteria that are normally harmless in their normal environment can cause problems if they grow in other parts of the body and can cause a range of infections with differing severity and associated mortality. One of the most serious infections Gram-negatives can cause bloodstream infections.

Gram-negative bacteria such as Escherichia coli, Klebsiella spp. and Pseudomonas aeruginosa are the leading causes of healthcare associated bloodstream infections. Gram-negative bacteria can be resistant to antibiotics and in some cases will be multi-resistant rendering most available antibiotics useless. Some of the antibiotic resistance mechanisms are on mobile genetic elements, such as plasmids, which allow the genes that encode resistance to spread more easily, and importantly, between different bacterial species.” Department of Health 2018

The will be an extended focus on reducing E.coli bloodstream infections. NHS Improvement recently stated “We have seen an increase in the number of E.coli bloodstream infections despite decreases in MRSA bloodstream infections and CDI infections”. The benefits of reducing these infections include improved patient safety through reduced infection rates, mortality, length of stay and appropriate antimicrobial prescribing • improved patient experience through the prevention of avoidable infections and reduced length of inpatient stay • improved population health through reduced antimicrobial resistance • potentially between £900-£2400 per patient saved for each E.coli BSI prevented (NHS Improvement).

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Good Governance Institute
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