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New Guidance from RCPath: Good Practice in the Diagnosis and Management of Sepsis

RCPath has published new guidance on the role of pathology in sepsis. It’s aimed at both lab and clinical teams, and looks at how pathology supports early detection, helps with clinical decision-making, and plays a key part in delivering better care.

“Sepsis is one of the leading causes of death in the UK but is frequently underreported on death certificates and other mortality statistics... One analysis suggests an annual figure of approximately 245,000 episodes of sepsis in adults in the UK each year, with 48,000 people dying as a result. This indicates sepsis claims more lives than breast, bowel or prostate cancers…Simple but timely interventions have been shown to significantly reduce mortality from sepsis, and very long delays are associated with increased mortality in those with septic shock. Despite this, sepsis often goes unrecognised in unwell and vulnerable patients and these interventions are often omitted, potentially leading to preventable deaths.”

National Medical Examiner April 2025

Key themes from the guidance include:

  • The importance of early recognition and escalation to senior decision makers.
  • The role of clinical and laboratory teams working together to support effective diagnosis and management.
  • The need for clear communication between laboratories and clinical teams, especially in relation to critical or unexpected results.
  • Support for training and education to improve awareness and understanding of sepsis across clinical and laboratory staff.
  • The importance of developing and reviewing local sepsis policies, with input from pathology.

Find out more on the guidance here  

Upcoming conference:
If you would like to explore this new guidance attend the upcoming:

Saving Lives Sepsis: Improving Practice & Outcomes

This conference focuses on ensuring early diagnosis and effective management of Sepsis, and improving outcomes through effective after care following sepsis infection. The conference will update delegates on the implementation of Martha’s Rule and the New national PIER system to improve the management of deterioration.

Date: Thursday 12th June 2025 (Virtual)
Details & Register:  www.healthcareconferencesuk.co.uk/virtual-online-courses/sepsis-practice 

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